论文部分内容阅读
目的:检测子宫内膜癌组织中血管内皮生长因子与突变型抑癌基因p53的表达情况,以探讨其在子宫内膜癌发生转移中的作用。方法:应用免疫组化S-P法检测45例子宫内膜癌及10例正常子宫内膜组织中VEGF和突变型p53的表达及其相关性,分析其与各临床病理参数之间的关系。结果:子宫内膜癌组织中VEGF及突变型p53蛋白表达阳性率均高于正常子宫内膜,两者呈显著正相关(P<0.01),两者阳性表达率均与临床分期、组织分化程度、淋巴结转移(P<0.05)有关,VEGF阳性表达率与肌层浸润深度无明显相关性(P>0.05),而突变型p53表达则与肌层浸润深度有关(P<0.05)。结论:VEGF和突变型p53与子宫内膜癌的发生、侵袭、转移和预后相关。
Objective: To detect the expression of vascular endothelial growth factor (VEGF) and mutant tumor suppressor gene p53 in endometrial carcinoma and to explore the role of VEGF in the metastasis of endometrial carcinoma. Methods: The expressions of VEGF and mutant p53 in 45 cases of endometrial carcinoma and 10 cases of normal endometrium were detected by immunohistochemical S-P method. The relationship between them and the clinicopathological parameters was analyzed. Results: The positive rates of VEGF and mutant p53 protein in endometrial carcinoma tissues were significantly higher than those in normal endometrium (P <0.01). The positive expression rates of VEGF and mutant p53 protein in both endometrial carcinoma tissues and clinical stage, histological differentiation , Lymph node metastasis (P <0.05). There was no significant correlation between the positive expression rate of VEGF and the depth of myometrial invasion (P> 0.05), while the expression of mutant p53 was related to the depth of myometrial invasion (P <0.05). Conclusion: VEGF and mutant p53 are associated with the occurrence, invasion, metastasis and prognosis of endometrial carcinoma.