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消炎痛具有松弛34周以内妊娠子宫的作用,但也发现它对胎儿可能引起一些严重的副作用,包括一过性、部分性的胎儿动脉导管狭窄和可逆性肾功能减退伴继发性羊水过少.苏灵达(Sulindac)化学名为:5-氟-2甲-1[4-(甲亚磺酰)苯甲烯]茚-3-乙酸,属于消炎痛的衍生物,美国早在1978年作为肌肉与骨骼炎性疾患的治疗剂开始应用于临床.苏灵达也是一种有效的前列腺素合成酶抑制剂,它是一种前体药物,在肝脏中转化为有活性的代谢物,半寿期达16小时,在尿中主要以无活性形式排出.动物实验中发现它很少或不经胎盘输送.鉴于以上这些特性,苏灵达应有可
Indomethacin has the effect of relaxing the uterus within 34 weeks of relaxation, but it has also been found to cause some serious side effects on the fetus, including transient, partial fetal ductal stenosis and reversible hypofunction with congenital oligohydramnios . Sulindac Chemical Name: 5-Fluoro-2-methyl-1 [4- (methylsulfinyl) -benzoate] indene-3-acetic acid, a derivative of indomethacin, as early as 1978 As a therapeutic agent for musculoskeletal inflammatory disorders, Sullivan is also a potent inhibitor of prostaglandin synthase, a prodrug that is converted to an active metabolite in the liver, half With a life span of 16 hours, it is mainly excreted in the urine in inactive form, and it has been found in animals that little or no transplacental delivery. In view of these characteristics,