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目的 明确2型糖尿病患者校正QT间期 (QT correction interval, QTc) 与非酒精性脂肪性肝病 (nonalcoholic fatty liver disease, NAFLD) 是否存在一定的相关性.方法 选取2017年7月-2018年6月在本院消化内科及内分泌科住院的549例2型糖尿病患者相关资料进行回顾性分析.QTc间期>440 ms为QTc+组, QTc间期≤440 ms为QTc-组.对可能影响QTc间期的因素进行Logistic回归分析.结果 男性 (OR=0.028, 95％CI 0.116～0.448, P=0.000) 和红细胞计数升高 (OR=0.231, 95％CI 0.081～0.662, P=0.006) 是糖尿病患者QTc间期延长的独立保护因素;心率增快 (OR=1.040, 95％CI 1.022～1.058, P=0.000) 、肥胖 (OR=3.350, 95％CI 1.885～5.951, P=0.000) 以及NAFLD (OR=1.999, 95％CI 1.192～3.352, P=0.009) 是糖尿病患者QTc间期延长的独立危险因素.结论 2型糖尿病患者QTc间期延长与超声检查确诊的NAFLD密切相关.“,”Objective To determine whether there is a certain correlation between QT correction interval (QTc) and non-alcoholic fatty liver disease in patients with type 2 diabetes.Methods Clinical data about 549 patients with type 2 diabetes in the department of gastroenterology and endocrinology in our hospital from July 2017 to June 2018 were selected for retrospective analysis.QTc interval>440 ms was defined as QTc+.QTc interval≤440 ms was defined as QTc-.Factors that might affect QTc interval, such as gender, heart rate, red blood cells, hemoglobin, etc., were analyzed by logistic regression analysis.Results Male (OR=0.028, 95％CI, 0.116-0.448, P<0.001) and elevated red blood cell (OR=0.231, 95％CI, 0.081-0.662, P=0.006) were independent protective factors of QTc interval prolongation in patients with diabetes.Elevated heart rate (OR=1.040, 95％CI, 1.022-1.058, P<0.001) , obesity (OR=3.350, 95％CI, 1.885-5.951, P<0.001) and NAFLD (OR=1.999, 95％CI, 1.192-3.352, P=0.009) were independent risk factors for the prolongation of QTc interval in patients with diabetes.Conclusion The prolongation of QTc interval in type 2 diabetic patients is closely related to NAFLD confirmed by ultrasonography.