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由法、美、英三国七位血液学工作者复习了约200例急性白血病的骨髓象和血象,从形态学上对本病分类提出新建议。他们将急性白血病分成二组——“原始淋巴细胞性”白血病与骨髓细胞性(Myeloid)白血病,前者分为L_1～3三型,后者分M_1～6六型。提出此分类旨在明确各种急性白血病的细胞形态,以利临床观察比较并可供免疫研究之参考。“原始淋巴细胞性”白血病三型的细胞特征见下本组中包括了未分化细胞性白血病,故不能径称为原始淋巴细胞性白血病。大多数L_3病例可找到B-淋巴细胞标记,而L_1和L_2仅25％左右的病例可找到T-淋巴细胞标记。骨髓细胞性白血病各型的细胞特征如下: M_1(原粒细胞性白血病不伴有成熟):>3％的原始细胞过氧化酶染色阳性,除原粒细胞外,未见进一步发育成熟的粒细胞。 M_2(原粒细胞性白血病伴有成熟):除原粒细胞外,可见早幼及进一步发育成熟的粒细胞。
Seven hematology workers from France, the United States and Britain reviewed about 200 cases of bone marrow and hemogram of acute leukemia and proposed new morphological classification of the disease. They divided acute leukemia into two groups - “primary lymphocytic” leukemia and myeloid leukemia, the former divided into L_1-3 type 3, the latter sub-M_1-6.6 type. This classification is proposed to identify a variety of acute leukemia cell morphology for clinical observation and comparison for immunological reference. The characteristics of “primitive lymphocytic leukemia type III cells” are included in this group, including undifferentiated cell leukemia, it can not be called primary lymphocytic leukemia. Most L_3 cases can find B-lymphocyte markers, while only about 25% of L_1 and L_2 can find T-lymphocyte markers. The characteristics of each type of myeloid leukemia are as follows: M 1 (MGE is not associated with maturation):> 3% of primary cells are positive for peroxidase staining, and no granulocytes are further developed except for myeloblasts . M_2 (Myeloid leukemia associated with maturity): In addition to the neutrophils, we can see early and further development of mature granulocytes.