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慢性粒细胞白血病(简称慢粒)的诊断,主要依据白细胞增多、血像及骨髓像粒细胞极度增生且左移、中性粒细胞碱性磷酸酶活性减低、出现Ph~1染色体。Ph~1染色体作为标记染色体也出现在粒、单系祖细胞(GMCFU)、红系祖细胞(CFU-E、BFU-E)、巨核系祖细胞(CFU-M)及B-淋巴细胞中。
Chronic myeloid leukemia (CML) diagnosis, mainly based on leukocytosis, hematopoietic and bone marrow hyperplasia granulocytes and left, neutrophil alkaline phosphatase activity decreased, Ph ~ 1 chromosome. The Ph ~ 1 chromosome also appears as a marker in GFP, GFP, CFU-E, CFU-M and B-lymphocytes.