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业已了解,肿瘤可由多个细胞株的肿瘤细胞亚群组成,这些亚群的核型,生长速度,转移能力,免疫学特征,表面标记以及对治疗的敏感性均有差异。这种异质性在一系列不同病因、不同组织和细胞来源和不同动物种系的动物肿瘤中均可观察到。人类肿瘤也被间接地证明存在着这种异质性。异质性并非恶性增生细胞所特有,癌前病变和正常细织也同样由细胞亚群组成。引起肿瘤细胞异质的可能机理包括肿瘤细胞株多个病灶的融合,和由单一细胞株衍生而来的不同细胞亚群。后者可以由遗传差错或与正常组织分化相同的细胞变异体形成。有时环境因子可以改变这一发生频率。非瘤细胞
It has been understood that tumors may consist of a subset of tumor cell populations from multiple cell lines. The karyotype, growth rate, metastatic capacity, immunological characteristics, surface markers, and sensitivity to treatment of these subpopulations are all different. This heterogeneity can be observed in a variety of animal tumors of different etiologies, different tissues and cell sources, and different animal strains. Human tumors have also been indirectly proven to have this heterogeneity. Heterogeneity is not unique to malignant proliferation cells. Precancerous lesions and normal fine weaves are also composed of subpopulations of cells. Possible mechanisms of tumor cell heterogeneity include the fusion of multiple lesions of a tumor cell line, and different cell subpopulations derived from a single cell line. The latter can be formed by genetic errors or the same cell variants as normal tissue differentiation. Sometimes environmental factors can change this frequency. Non-neoplastic cells