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目的:观察磷酸肌酸钠对胃癌术后疲劳综合征患者免疫功能的影响。方法:将165例胃癌患者分为两组,在手术后1~3 d治疗组85例静脉滴注磷酸肌酸钠,对照组80例静脉滴注等容积生理盐水;记录术前及术后第1、3、5、9 d疲劳评分(VAS评分),检测术前及术后第1、3、5、9 d两组免疫球蛋白IgA、IgG、IgM及免疫细胞亚群CD3+、CD4+、CD4+/CD8+水平。结果:两组患者术后VAS评分较术前显著升高,治疗组升高程度低于对照组(P<0.05);术后血清IgA、IgG、IgM、CD3+、CD4+、CD4+/CD8+水平均明显下降,对照组降低更为明显(P<0.05)。结论:磷酸肌酸钠能够明显减轻患者胃癌术后疲劳综合征,改善免疫状况,有利于改善生活质量。
Objective: To observe the effect of sodium creatine phosphate on immune function in patients with postoperative fatigue syndrome of gastric cancer. Methods: 165 patients with gastric cancer were divided into two groups. One to three days after operation, 85 patients in the treatment group received intravenous instillation of sodium creatine phosphate, and 80 in the control group received intravenous infusion of equal volume of normal saline. 1, 3, 5 and 9 d fatigue scores (VAS score). The levels of immunoglobulin IgA, IgG, IgM and immune cell subsets CD3 +, CD4 +, CD4 + / CD8 + level. Results: The postoperative VAS scores of the two groups were significantly higher than those before the operation, and the levels of the treatment group were lower than those of the control group (P <0.05). The levels of serum IgA, IgG, IgM, CD3 +, CD4 +, CD4 + / CD8 + Decreased, the control group decreased more significantly (P <0.05). Conclusion: Sodium creatine phosphate can significantly reduce postoperative fatigue syndrome in patients with gastric cancer, improve immune status, and help to improve the quality of life.