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HSV-2与宫颈鳞状细胞癌有病因学关系的设想最初是基于血清学和流行病学的研究。支持这种设想的证据来自在肿瘤细胞中发现有病毒抗原的表达,以及在一些肿瘤中检测出了病毒RNA和DNA.而且HSV-1和HSV-2能转化啮齿类细胞成恶性表现型。越来越多的证据说明,细胞能够在缺乏检测疱疹病毒序列的情况下维持转化,即使起动转化也不需要有一种蛋白质.这些观察有力地支持下述假设:HSV以一种“打了就跑”的方式起作用,诱导细胞发生改变,以致引起癌化。因此,作者认为:
The idea of an etiological relationship between HSV-2 and cervical squamous cell carcinoma was initially based on serological and epidemiological studies. Evidence supporting this idea stems from the discovery that viral antigens are expressed in tumor cells, as well as viral RNA and DNA in some tumors, and that HSV-1 and HSV-2 can transform rodent cells into malignant phenotypes. There is growing evidence that cells are capable of maintaining their transformation in the absence of a herpesvirus detection sequence and that there is no requirement for a protein to prime the conversion.These observations strongly support the hypothesis that HSV is “ ”Way to play a role in inducing cell changes that cause cancer. Therefore, the author thinks: