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目的:探讨母体长期处于低硒状态下是否对子代哺乳期生长发育影响。方法:将正常成年雌性SD大鼠随机分为低硒实验组(SR)和正常对照组(NC),分别使用常硒和自制低硒饲料喂养,4周后,确定低硒动物模型建立成功后并分别进行合笼。从子代出生开始,通过记录两组子代大鼠哺乳期的各项生长发育指标并检测子代体内硒含量,探讨母体低硒对子代哺乳期生长发育的影响。结果:低硒实验组子代SD大鼠体长及体重均低于正常对照组,并且低硒实验组子代SD大鼠的死亡率较正常对照组高;低硒实验组子代SD大鼠肝脏、心脏、肾脏以及血液中的硒含量均明显低于正常对照组;低硒实验组子代SD大鼠的心脏、肝脏及肾脏重量,均低于正常对照组。结论:母体长期处于低硒状态下,将对子代哺乳期的生长发育造成严重影响。
Objective: To investigate whether the long-term maternal low selenium status on the growth and development of lactating mothers offspring. Methods: Normal adult female Sprague-Dawley rats were randomly divided into low-selenium group (SR) and normal control group (NC), and were fed with normal selenium and low-selenium diet respectively. After 4 weeks, And were caged separately. From the birth of the offspring, the indexes of growth and development of the offspring of the two offspring rats were recorded and selenium contents in the offspring were detected to explore the effect of maternal low selenium on the lactation growth and development of the offspring. Results: The body length and body weight of offspring SD rats were lower than those of normal control group, and the mortality rate of SD rats in offspring selenium group was higher than that of normal control group. SD selenium rats The selenium contents of liver, heart, kidney and blood were significantly lower than those of the normal control group. The heart, liver and kidney weights of SD rats were lower than those of normal control group. Conclusion: The maternal long-term low selenium status will have a serious impact on the growth and development of the offspring during lactation.