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为了了解国人人群脂蛋白(a)的分布及水平,探讨脂蛋白(a)与冠心病及其它血脂与载脂蛋白的关系,本文应用单价抗载脂蛋白(a)及抗载脂蛋白B抗体夹心酶联法测定668名健康人血浆脂蛋白(a),测得(?);122.34±141.97mg/L,M为81.07mg/L(0～1 250mg/L),呈典型的正偏态分布,无性别年龄差异,与其它脂类及载脂蛋白不相关。48例冠心病患者血浆脂蛋白(a)水平及>200mg/L的频率分布均明显高于同年龄对照组,提示高脂蛋白(a)水平是致动脉粥样硬化的一个独立危险因素。
In order to understand the distribution and level of lipoprotein (a) in Chinese population and to explore the relationship between lipoprotein (a) and coronary heart disease and other blood lipids and apolipoproteins, we used monovalent anti-apolipoprotein (a) and anti-apolipoprotein B Sandwich enzyme-linked immunosorbent assay (ELISA) was used to determine the plasma lipoprotein levels in 668 healthy subjects (?), 122.34 ± 141.97 mg / L and 81.07 mg / L M (0-1 250 mg / L) Distribution, no gender differences in age, and other lipids and apolipoproteins are not related. The plasma lipoprotein (a) level and the frequency distribution of> 200mg / L in 48 patients with coronary heart disease were significantly higher than those of the same age control group, suggesting that the level of serum lipoprotein (a) is an independent risk factor for atherosclerosis.