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地点:市中心人类免疫缺陷病毒(HIV)门诊部目标:在存在潜伏性结核感染(LTBI)危险因素的HIV感染人群中评估结核菌素皮肤试验(TST)和QuantiFERON-TB GOLD(QFT-G)试验。实验设计:对已知的LTBI危险因素与早期分泌性靶抗原6(ESAT-6)和培养分泌蛋白10 (CFP-10)刺激的全血γ-干扰素释放试验及TST试验进行统计学横断面分析。结果:纳入的207例病例中,4例由于信息丢失或者3次标本检测结果不一致而被排除。10例由于对促细胞分裂素反应不良结果不能确定。所有的不确定结果发生在CD4细胞数目低于200个/ mm~3的患者。11例QFT-G和13例TST结果阳性。QFT-G和TST结果之间的一致性较低(κ0.38)。QFT-G结果同TST相比与LTBI危险因素相关的可能性更大。结论:QFT-G试验而非TST表现出在LTBI危险因素数目与阳性结果之间具有显著性差异(OR1.6)。QFT-G试验在HIV感染人群中可能较TST试验更有价值。
Location: Downtown Human Immunodeficiency Virus (HIV) Outpatient Department Goal: To assess the efficacy of the tuberculin skin test (TST) and QuantiFERON-TB GOLD (QFT-G) in HIV-infected individuals with risk factors for latent tuberculosis (LTBI) test. Experimental Design: Statistical cross-sections of known LTBI risk factors with the whole-blood IFN-gamma released from ESAT-6 and CFP-10 stimulation and the TST test analysis. Results: Of the 207 cases enrolled, 4 were excluded because of missing information or inconsistencies in 3 specimens. 10 cases due to poor response to cytokinin results can not be determined. All the uncertainties occurred in patients with CD4 cells less than 200 cells / mm3. 11 cases of QFT-G and 13 cases of TST positive results. The consistency between QFT-G and TST results is low (κ0.38). QFT-G results are more likely to be associated with LTBI risk factors than TST. CONCLUSIONS: QFT-G tests, but not TST, showed a significant difference (OR 1.6) between the number of LTBI risk factors and positive results. The QFT-G test may be more valuable than the TST test in HIV-infected individuals.