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目的了解北京市顺义区健康人群甲型H1N1流感抗体水平,评价甲型H1N1流感疫苗免疫效果,为卫生部门制定预防控制措施和策略提供依据。方法随机选取顺义区12个乡街的5岁以上健康人群(202名)采集免疫前静脉血检测抗体,评估健康人群抗体水平;接种甲型H1N1流感疫苗后,各年龄组随机选取部分人群做免疫后抗体水平检测,评估疫苗免疫效果。结果 202份血清标本中甲型H1N1流感抗体水平阳性率46.53%(94/202),与北京市人群甲型H1N1流感抗体水平检测结果差异有统计学意义。抗体几何平均滴度倒数(GMRT)为32.78。不同性别人群之间甲型H1N1流感抗体阳性率差异无统计学意义,不同年龄组之间抗体水平阳性率差异有统计学意义,25~29岁、10~14岁组抗体水平阳性率高。50名评估对象免疫前抗体阳性率50%(25/50),免疫后抗体阳性率94%(47/50),甲型H1N1流感抗体阳转率80%(30/50)。免疫前阴性和阳性评估对象之间抗体阳转率差异有统计学意义。评估对象总体抗体滴度呈6倍增高,各年龄组免疫前、后抗体GMRT的变化之间差异有统计学意义,25~29岁、60岁以上组滴度升高倍数最低。结论顺义区甲型H1N1流感实际感染数高于北京市甲型H1N1流感平均感染水平。疫苗接种使目标人群达到了形成该样本人群免疫屏障的要求,提示在甲型H1N1流感大流行之际接种疫苗是控制疫情的必要手段。免疫前抗体水平、年龄是甲型H1N1流感抗体阳转率的影响因素。
Objective To understand the antibody level of Influenza A (H1N1) in healthy population in Shunyi District of Beijing and to evaluate the immunization effect of Influenza A (H1N1) vaccine and to provide basis for the prevention and control measures and strategies of health department. Methods A total of 202 healthy volunteers (202 healthy volunteers) aged 12 and above in Shunyi District were enrolled in this study. Pre-immune venous blood samples were collected to assess antibody levels in healthy population. After vaccination, influenza A (H1N1) After the antibody level test to assess the vaccine immune effect. Results The positive rate of influenza A (H1N1) antibody in the 202 samples was 46.53% (94/202), which was significantly different from that of the Beijing population. Antibody geometric mean titer reciprocal (GMRT) was 32.78. There was no significant difference in the positive rate of influenza A (H1N1) antibody between different sex groups. The positive rate of antibody in different age groups was statistically different. The positive rate of antibody in 25 ~ 29 years old and 10 ~ 14 years old group was high. The positive rate of antibody before immunization was 50% (25/50), the positive rate of antibody after immunization was 94% (47/50), and the rate of positive rate of influenza A (H1N1) virus was 80% (30/50). There was significant difference in antibody positive rate between pre-immunization negative and positive subjects. The total antibody titers of the subjects increased 6-fold. There was a significant difference in GMRT between before and after immunization among all age groups. The titers of increase of GMRT between 25-29 and 60-year-old groups were the lowest. Conclusion The actual number of influenza A (H1N1) infections in Shunyi District is higher than the average level of influenza A (H1N1) in Beijing. Vaccination allowed the target population to reach the immunological barrier required to establish the sample population, suggesting that vaccination is a necessary tool to control the outbreak during the pandemic. Pre-immune antibody levels, age, Influenza A H1N1 influenza antibody positive rate of influencing factors.