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目的探讨男性不育症中少精子症、严重少、弱、畸精子症和无精子症与染色体异常的关系。方法采用外周血淋巴细胞培养,常规制备染色体,应用G显带技术进行核型分析。结果在精液分析异常的567例患者中共发现1 01例染色体异常,异常率为1 7.8%(1 01/567)。在少精子症、严重少、弱、畸精子症和无精子症患者中异常染色体检出率分别为6.8%(6/88)、1 5.4%(2/1 3)、14.3%(3/21)、0%(0/1)和20.3%(90/444)。还发现各种类型的染色体多态51例,发生率为9.0%(51/567)。结论染色体的异常是精子发生障碍的原因之一,染色体检查对精液分析异常患者的诊断与治疗有重要意义。
Objective To investigate the relationship between oligozoospermia, oligozoospermia, oligozoospermia, azoospermia and chromosomal abnormalities in male infertility. Methods Peripheral blood lymphocytes were cultured and chromosomes were routinely prepared. K - banding technique was used to analyze the karyotype. Results A total of 101 chromosomal abnormalities were detected in 567 patients with abnormal semen analysis, with an abnormality rate of 1 7.8% (101/567). The detection rates of abnormal chromosomes were 6.8% (6/88), 14.4% (2/1 3), 14.3% (3/21) in patients with oligospermia, severe oligoarthritis, oligozoospermia, oligozoospermia and azoospermia, respectively ), 0% (0/1) and 20.3% (90/444). Also found in 51 cases of various types of chromosome polymorphism, the incidence was 9.0% (51/567). Conclusion Chromosomal abnormalities are one of the reasons for the dysfunction of spermatogenesis. Chromosome examination is of great significance for the diagnosis and treatment of patients with abnormal semen analysis.