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作者回顾了γ干扰素的生物学特性以及其在宿主中的防御机能,免疫调节和免疫病理方面的最新认识,对新生儿和免疫缺陷宿主中γ干扰素产生减少的意义和其基础,以及作为治疗剂的现状和展望作了简要的论述。γ干扰素是由被激活的T淋巴细胞和NK细胞(自然杀伤淋巴细胞)分泌的一种分子量为20000～25000的糖蛋白。在众多的淋巴因子中,γ干扰素具有独特的遗传学特征,需与特异性受体结合才能发挥作用。其受体
The authors review the biological properties of gamma interferon as well as its current defensiveness in the host, recent understanding of immunomodulatory and immunopathological aspects, its significance for the reduction of gamma interferon production in neonatal and immunocompromised hosts, and its rationale as The status and prospects of therapeutic agents made a brief discussion. Interferon gamma is a glycoprotein with a molecular weight of 20,000-25,000 secreted by activated T lymphocytes and NK cells (natural killer lymphocytes). Of the many lymphokines, gamma interferon has a unique genetic profile that requires binding to specific receptors to function. Its receptor