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化学名 4-(6-甲氧基-2-萘基)丁酮-2 药效分类非类固醇消炎药开发单位 (英)Bencard 上市厂商 (英)Bencard 1987年3月药理本品为一新非类固醇消炎药,主要用于风湿病的治疗。该药是一种非酸性药物前体,在肝脏内被快速代谢为作用更强的化合物。本品的口服制剂,对胃内前列腺素的生物合成过程具有较弱的抑制作用。内窥镜研究证实,本品对胃的刺激远远小于萘普生、吲哚美辛和阿司匹林。药动学本品口服后,主要经肝脏代谢,其主要代谢产物有较高的蛋白结合率。代谢产物主要从尿中排泄。适应症主要用于骨关节炎和风湿性关
Chemical name 4- (6-methoxy-2-naphthyl) butanone -2 Pharmacodynamic classification Non-steroidal anti-inflammatory drug development unit Bencard Listing manufacturer Bencard 1987 March Pharmacological This product is a new non Steroid anti-inflammatory drugs, mainly for the treatment of rheumatism. The drug is a non-acidic pro-drug that is rapidly metabolized in the liver to more potent compounds. This product oral preparations, the stomach of prostaglandin biosynthesis process has a weak inhibitory effect. Endoscopic studies have confirmed that this product on the stomach is far less than the stimulation of naproxen, indomethacin and aspirin. Pharmacokinetics After oral administration, mainly by the liver metabolism, the main metabolites have a high protein binding rate. Metabolites are mainly excreted from the urine. Indications are mainly used for osteoarthritis and rheumatism