因为大多数的致癌基因包括第一次确定了的序列在内都是从培养了许多代的肿瘤细胞系衍生的,从而很自然提出这些假定的致癌基因是否可能为细胞培养的赝象。但国立肿瘤研究所细胞和分子生物学实验室最近报告的资料表明,从各种实体瘤细胞中能发现癌基因,这些实体瘤都是从病人体内经手术切除后,在低温冷 Because most of the oncogenes, including the first identified sequences, were derived from tumor cell lines that had been cultured for many generations, it is natural to suggest that these putative oncogenes may be an artifact of cell culture. However, data from the National Cancer Institute’s Cell and Molecular Biology Laboratory recently reported that oncogenes can be found in a variety of solid tumor cells that have been surgically resected from the patient’s body and cooled at low temperatures.