肝素是临床上常用的抗凝剂,肝素诱导的血小板减少症(HIT)是肝素治疗的严重并发症,表现为由免疫介导所致的血小板大量丢失[1]。血小板减少一般发生在应用肝素后的第5-14d内,血小板较基础值下降50%或绝对值降至50×109/L-80×109/L,而停用肝素后血小板计数一般可在1周内恢复正常,临床 Heparin is a commonly used clinical anticoagulant. Heparin-induced thrombocytopenia (HIT) is a serious complication of heparin therapy and manifests as a massive loss of platelets due to immune-mediated [1]. Thrombocytopenia usually occurs within 5-14 days after heparin is applied. Platelets decrease 50% or absolute value from baseline to 50 × 109 / L to 80 × 109 / L, whereas platelet counts after heparin withdrawal are generally 1 Week back to normal, clinical