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[目的]运用Meta分析方法综合分析评价月经生育因素与中国女性乳腺癌的关系。[方法]收集国内有关乳腺癌月经生育因素的病例对照研究文献22篇,采用可信区间方差分析法计算各相关因素的ORc及95%CI。[结果]各研究因素的ORc及95%CI分别为:初潮年龄ORc=0.540(0.450～0.648)、结婚年龄1.376(0.815～2.322)、初产年龄1.558(1.253～1.937)、生育与否0.718(0.320～1.616)、生育胎数0.97(0.705～1.335)、哺乳0.391(0.253～0.605)、哺乳时间0.94(0.884～0.999)、人工流产1.844(1.442～2.358)、绝经与否1.869(1.014～3.444)、绝经年龄1.034(0.706～1.515)、行经期1.223(1.034～1.446)、月经紊乱3.217(2.278～4.542)、月经周期0.446(0.372～0.535)、口服避孕药1.400(0.977～2.006)。[讨论]初潮年龄、哺乳和哺乳时间是乳腺癌的保护因素,初产年龄、人工流产、绝经及行经期是乳腺癌的危险因素,结婚年龄、生育、生育胎数、绝经年龄、月经紊乱、月经周期和口服避孕药与乳腺癌关系尚不明确,有待进一步研究。
[Objective] To evaluate the relationship between menstrual growth factors and breast cancer in Chinese women by Meta-analysis. [Methods] Twenty-two case-control literatures about menstrual reproductive factors of breast cancer in China were collected, and the ORC and 95% CI of all relevant factors were calculated by the method of confidence interval analysis. [Results] The ORc and 95% CI of the study factors were: ORC = 0.540 (0.450-0.648), 1.376 (0.815-2.322), 1.558 (1.253-1.937), and 0.718 0.320 ~ 1.616), the number of births 0.97 (0.705-1.335), lactation 0.391 (0.253-0.605), lactation time 0.94 (0.884-0.999), induced abortion 1.844 (1.442-2.358), and postmenopausal or not 1.869 (1.014-3.444) , Menopausal age 1.034 (0.706 ~ 1.515), menstrual period 1.223 (1.034 ~ 1.446), menstrual disorders 3.217 (2.278 ~ 4.542), menstrual cycle 0.446 (0.372 ~ 0.535) and oral contraceptives 1.400 (0.977 ~ 2.006). [Discussion] Age, lactation and breastfeeding time are the protective factors of breast cancer. The age at first birth, induced abortion, menopause and menstrual period are the risk factors of breast cancer, the age of marriage, birth, the number of births, menopause, menstrual disorders, Menstrual cycle and oral contraceptives and breast cancer is not yet clear, pending further study.