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目的：确定是否可通过阻断透明质酸的细胞表面受体ＣＤ４４Ｈ与它的配体的结合而抑制肿瘤生长。方法：观察ＣＤ４４Ｈ和免疫球蛋白的可溶性融合蛋白（ＣＤ４４Ｒｇ）对转染并稳定表达ＣＤ４４Ｈ的人Ｎａｍａｌｗａ淋巴瘤细胞生长的影响。结果：ＣＤ４４Ｒｇ可抑制Ｎａｍａｌｗａ肿瘤细胞在裸鼠体内形成肿瘤的能力，但对该细胞的体外生长则无影响。结论：破坏ＣＤ４４Ｈ与其生理学配体之间的作用，可能成为控制肿瘤在体内生长的一种新的手段。
Purpose: To determine whether tumor growth can be inhibited by blocking the binding of the hyaluronic acid cell surface receptor CD44H to its ligand. METHODS: The effects of CD44H and immunoglobulin soluble fusion protein (CD44Rg) on the growth of human Namalwa lymphoma cells transfected and stably expressing CD44H were observed. RESULTS: CD44Rg inhibited the ability of Namalwa tumor cells to form tumors in nude mice, but had no effect on the growth of the cells in vitro. Conclusion: The disruption of the role of CD44H and its physiological ligands may be a new means of controlling the growth of tumors in vivo.