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目的研究手术和放射治疗喉癌对患者甲状腺功能和营养状况的影响。方法将40例喉癌患者分为手术结合放疗的观察组,及单纯手术治疗的对照组,观察其治疗前后甲状腺功能、血液生化学变化以及营养状况。结果治疗前,两组患者的血清TSH水平、T3、T4浓度、血液生化学各项指标比较,差异无统计学意义(P>0.05);治疗后,同组甲状腺功能治疗前后比较,差异有统计学意义(P<0.01).治疗前,与对照组比较,观察组的TP、PA水平升高明显,A、TF则降低明显,差异有统计学意义(P<0.05)。观察组的各项营养评估水平均优于与对照组,差异有统计学意义(P<0.05)。结论手术结合放射治疗喉癌,对于甲状腺功能,尤其是甲减这一并发症的改变不明显,但可以改善患者的血液指标,以及提高其营养水平。
Objective To study the effects of surgery and radiotherapy on thyroid function and nutritional status in patients with laryngeal cancer. Methods Forty patients with laryngeal cancer were divided into two groups: operation group combined with radiotherapy and operation group, and thyroid function, blood biochemical changes and nutritional status before and after treatment. Results Before treatment, the levels of serum TSH, the concentrations of T3 and T4 and the indexes of blood biochemistry were not significantly different between the two groups (P> 0.05). After treatment, the difference was statistically significant before and after the treatment of thyroid function (P <0.01) .Compared with the control group before treatment, TP and PA levels in the observation group increased significantly, and A and TF decreased significantly (P <0.05). The nutritional assessment of the observation group were better than the control group, the difference was statistically significant (P <0.05). Conclusion The combination of surgery and radiotherapy of laryngeal cancer has no obvious change on the thyroid function, especially hypothyroidism, but can improve the patient’s blood index and improve the nutrition level.