例1，女，12岁，其父代诉患儿出生后即四肢关节经常“啪啪”作响，但无过伸及脱位发生。近1年来症状加重，且出现乏力，心悸、多梦，消瘦。查体：T36．5℃，P97次／分，R28次／分，BP12／gkPa身高159cm。体重36．5kg，精神差，表情淡漠，面容推怀，貌似中年人，皮下脂肪极薄， Example 1, female, 12 years old, his father complained of children with limbs after birth often “flapping” sound, but no overshoot and dislocation occurred. Over the past year the symptoms have worsened, and there is fatigue, palpitations, dreams, weight loss. Examination: T36.5 ℃, P97 times / min, R28 times / min, BP12 / gkPa height 159cm. Weight 36.5kg, poor spirit, expression indifferent, pushing the face, looks like middle-aged, very thin subcutaneous fat,