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目的:系统评价口腔颊黏膜对比舌黏膜尿道成形术的有效性和安全性。方法:计算机检索PubMed、Cochrane Library、Embase、CNKI、万方数据库、CBM数据库,按照纳入和排除标准选择临床研究,评价纳入文献质量并提取资料,采用RevMan 5.3软件进行Meta分析。结果:共纳入7篇病例对照研究,357例患者中颊黏膜尿道成形术组患者178例,舌黏膜尿道成形术组患者179例。Meta分析结果显示:两组手术成功率差异无统计学意义[OR=0.85,95%CI(0.48,1.51),P=0.57]。对手术后并发症和供区部位并发症定性评价显示:颊黏膜尿道成形术组患者易发生口周麻木、张口困难等术后并发症,舌黏膜尿道成形术组患者易发生发音改变等术后并发症。结论:颊黏膜尿道成形术和舌黏膜尿道成形术均是治疗前尿道狭窄的有效治疗方法,两者在手术成功率上无明显差异。舌黏膜取材较颊黏膜更加便利,可能更加有利于手术操作。
Objective: To systematically evaluate the effectiveness and safety of oral buccal mucosa versus lingual mucosa urethroplasty. METHODS: PubMed, Cochrane Library, Embase, CNKI, Wanfang database and CBM database were searched by computer. The clinical studies were selected according to inclusion and exclusion criteria. The quality of the included documents was extracted and the data were extracted. Meta-analysis was performed using RevMan 5.3 software. Results: A total of seven case-control studies were enrolled in the study, including 178 cases of buccal mucosal urethroplasty in 357 patients and 179 cases of lingual mucosal urethroplasty. Meta analysis showed that there was no significant difference in the surgical success rates between the two groups [OR = 0.85, 95% CI (0.48, 1.51), P = 0.57]. The postoperative complication and the qualitative evaluation of the complications of the donor site showed that postoperative complications such as perioral numbness and difficulty of opening were easy to occur in the buccal mucosa urethroplasty patients. complication. Conclusions: Both buccal mucosal urethroplasty and lingual mucosa urethroplasty are effective methods for the treatment of pre-urethral stricture. There is no significant difference in the success rate between the two methods. Tongue mucosa taken more convenient than buccal mucosa, may be more conducive to surgical procedures.