脓毒性休克又称感染性休克,是血液分布性休克的一种特殊类型,全世界死亡率极高,虽然从2001年开始各个国家采取了拯救脓毒症措施并发表了一系列指南指导临床,死亡率有所下降,但目前仍是ICU病房以及急危重症患者的首位死亡原因[1]。乌司他丁是近年来被用于治疗脓毒性休克的常用药物,尤其是大剂量乌司他丁的使用,为治疗脓毒性休克开创了新的途径,值得我们临床探索与研究。1脓毒性休克的相关概念及发病机制 Septic shock, also known as septic shock, is a special type of blood-borne shock and has a high worldwide mortality rate. Although various countries took measures to rescue sepsis and issued a series of guidelines to guide clinical practice since 2001, Mortality rates have declined but are still the leading cause of death in ICU wards and critically ill patients [1]. Ulinastatin, a commonly used drug used to treat septic shock in recent years, especially the use of high-dose ulinastatin, has opened a new avenue for the treatment of septic shock and deserves our clinical exploration and research. 1 septic shock related concepts and pathogenesis