非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是一种无过量饮酒史,病变主体在肝小叶,以肝细胞弥漫性脂肪变性和脂肪贮积为主的临床病理综合征。事实上,NAFLD被认为是代谢综合征的肝脏表现,属胰岛素抵抗(insulin resistance,IR)相关症候群。NAFLD与代谢综合征之间的联系已经得到许多横断面及前瞻性研究的证实[1,2]。研究发现,脂联素(adiponectin,apM1)及其受体影响糖、脂代谢;而 Non-alcoholic fatty liver disease (NAFLD) is a clinical history of pathology without excess alcohol consumption, mainly in the hepatic lobules, diffuse hepatic steatosis and fatty deposits. In fact, NAFLD is considered a liver manifestation of the metabolic syndrome and is a syndrome associated with insulin resistance (IR). The link between NAFLD and metabolic syndrome has been confirmed by many cross-sectional and prospective studies [1,2]. The study found that adiponectin (apM1) and its receptor affect the metabolism of sugar and lipid; and