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目的探讨新生儿脐血神经生长因子(nerve growth factor,NGF)测定的临床意义。方法采用放射免疫分析法测定200例无缺氧史新生儿、97例有缺氧高危因素足月新生儿脐动脉血中β-NGF表达水平,200例无缺氧史新生儿中足月儿140例,早产儿60例;97例有缺氧高危因素足月新生儿分为3组:重度窒息组25例,子痫组40例,妊娠期糖尿病组32例。结果早产儿脐动脉血β-NGF水平明显低于正常足月产儿(P<0.05),有缺氧高危因素足月新生儿脐血中β-NGF水平明显低于无缺氧史足月新生儿(P<0.05),β-NGF水平与新生儿性别、体质量及分娩方式无明显关系。结论神经生长因子与胎儿生长发育可能有一定关系,可以客观反映新生儿出生时的状况,对协助判断新生儿预后有指导意义。
Objective To investigate the clinical significance of determination of nerve growth factor (NGF) in neonatal cord blood. Methods Radioimmunoassay was used to determine the expression of β-NGF in umbilical arterial blood of 200 neonates without hypoxia and 97 neonates with high risk of hypoxia. Cases, 60 cases of premature children; 97 cases of high risk factors of hypoxia term neonates were divided into 3 groups: 25 cases of severe asphyxia group, 40 cases of eclampsia group, gestational diabetes mellitus group of 32 cases. Results The level of β-NGF in umbilical artery of premature infants was significantly lower than that of normal term infants (P <0.05). The level of β-NGF in umbilical blood of full-term newborns with high risk of hypoxia was significantly lower than that of full-term neonates without hypoxia (P <0.05). There was no significant relationship between β-NGF level and neonatal gender, body weight and delivery mode. Conclusion Nerve growth factor and fetal growth may have a certain relationship, can objectively reflect the status of newborns at birth, to help determine the prognosis of newborn guidance.