抗病毒治疗是慢性乙型肝炎治疗的重要手段。目前单一药物的疗效不令人满意,越来越多的研究数据表明药物联合抗病毒治疗,包括干扰素α和核苷(酸)类似物联合治疗以及两种核苷(酸)类似物联合治疗可以减少耐药发生、提高抗病毒疗效,因而联合抗病毒治疗可能是控制乙肝的有效策略。 Antiviral therapy is an important treatment for chronic hepatitis B. At present, the effect of a single drug is not satisfactory, and more and more research data show that the combination of antiviral drugs and interferon alpha and nucleoside (acid) analogs and the combination of two nucleoside (acid) analogues Can reduce the incidence of drug resistance and improve the anti-virus efficacy, and thus combined antiviral therapy may be an effective strategy to control hepatitis B.