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用细胞毒药物(马利兰、6-硫鸟嘌呤或苯丁酸氮芥)治疗克隆性骨髓增生性疾患、骨髓纤维化(MF),临床是有效和安全的。但上述药物的远期致白血病的可能仍是主要考虑的问题。羟基脲很少诱发白血病。本文报道用羟基脲作为首选药物治疗10例 MF 病人的结果。病人和方法男4、女6例。年龄53～82岁。开始治疗时间;由确诊当时至确诊后9年。病者均有症状性脾大,多数有贫血,部份有白细胞和血小板增高,少数人有全身消耗症状。羟基脲剂量为15
Treatment of clonal myeloproliferative disorders, myelofibrosis (MF) with cytotoxic drugs (Maryland, 6-thioguanine or chlorambucil) is clinically effective and safe. However, the long-term drug-induced leukemia may still be a major concern. Hydroxyurea seldom induces leukemia. This article reports the results of treating 10 MF patients with hydroxyurea as the drug of choice. Patients and methods male 4, female 6 cases. Age 53 ~ 82 years old. Start treatment time; from the time of diagnosis to 9 years after diagnosis. Symptomatic patients have splenomegaly, most have anemia, some have increased white blood cells and platelets, a small number of people have systemic symptoms. Hydroxyurea dose 15