论文部分内容阅读
本文观察10例健康人与12例高血压病人以可乐定(clonidine)诱发生长激素释放的区别,还观察在β受体阻断剂普洛察尔(propranolol)作用1周后,10例高血压病人可乐定/生长激素(C/GH)的变化。研究证明:静注中枢神经α_2受体激动剂可乐定150μg后30,60min使正常人血清生长激素分别增加7.8与6.4倍,高血压病人仅分别增加2.3与1.7倍(P<0.01),高血压病人的中枢α_2受体对激动剂反应性下降。10例病人接受普洛萘尔治疗1周后,在已经出现明显的心率减慢,可乐定的降压作用已被抑制的同时,病人可乐定/生长激素反应低下的现象未能纠正。提示高血压病人中枢α_2受体功能障碍,可能是选择性的。
This article observed 10 healthy subjects and 12 patients with hypertension in patients with clonidine-induced growth hormone release difference, also observed in the beta-blocker propranolol effect after 1 week, 10 cases of hypertension Patient clonidine / growth hormone (C / GH) changes. Studies have shown that: intravenous injection of clonidine α2 receptor agonist 150μg after 30,60 min so that normal serum growth hormone were increased 7.8 and 6.4 times, respectively, hypertensive patients increased by 2.3 times and 1.7 times (P <0.01), hypertension The patient’s central α_2 receptor decreased agonist response. One week after the 10 patients received palliative treatment, clonidine / growth hormone response was poorly corrected despite significant slowing of heart rate and clonidine’s antihypertensive effect had been suppressed. Tip Hypertensive patients with central α_2 receptor dysfunction, may be selective.