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超氧化物歧化酶(SOD)的抑制剂二乙基二硫代氨基甲酸钠(DDC)既能加强抗癌药的药效,又能提高细胞的辐射敏感性,因此是一种有希望的肿瘤化疗及放疗综合疗法的试剂。我们曾发现它能使癌细胞的SOD活性下降,癌细胞的存活率下降,对癌细胞集落形成率、DNA合成和细胞形态都呈双时相毒性。它也能抑制癌细胞的增殖率,延长细胞倍增时间。由于SOD活性与DNA合成的变化密切相关,因而SOD活性的大小对癌细胞受DDC中毒时能否存活起重要作用。本文着重研究DDC对癌细胞SOD活性的影响以及SOD在细胞中毒中的作用。
The inhibitor of superoxide dismutase (SOD) sodium diethyldithiocarbamate (DDC) can not only enhance the efficacy of anticancer drugs, but also increase the radiation sensitivity of cells, so it is a promising cancer chemotherapy. And radiotherapy combined therapy reagents. We have found that it can decrease the SOD activity of cancer cells, decrease the survival rate of cancer cells, and show double phase toxicity to the colony formation rate, DNA synthesis, and cell morphology of cancer cells. It can also inhibit the proliferation rate of cancer cells and prolong the doubling time of cells. Since SOD activity is closely related to changes in DNA synthesis, the size of SOD activity plays an important role in the survival of cancer cells when DDC is poisoned. This article focuses on the effects of DDC on SOD activity in cancer cells and the role of SOD in cell poisoning.