目的 :研究遗传因素在肝癌发生中的作用。方法 :通过遗传流行病学病例对照研究 ,应用Li Mantel和Falconer方法进行肝癌的分离比及遗传度的估算。结果 :泰兴市肝癌的分离比为 0 12 71,明显低于 0 2 5 ,属于多基因遗传方式 ;遗传度为 35 74 % ,其中男性 (30 5 6% )明显低于女性 (5 4 90 % )。结论 :遗传因素是肝癌的危险因素之一 ,但不是泰兴市肝癌高发的主要危险因素 Objective: To study the role of genetic factors in the development of liver cancer. Methods: By genetic and epidemiological case-control study, Li Mantel and Falconer methods were used to estimate the isolation ratio and hereditary degree of HCC. Results: The segregation ratio of hepatocellular carcinoma in Taixing was 0 12 71, which was significantly lower than 0 2 5, which belonged to polygene inheritance. The heritability was 35 74%, of which male (30 56%) was significantly lower than female (54 90% ). Conclusion: Genetic factors are one of the risk factors for liver cancer, but not the major risk factor for liver cancer in Taixing