论文部分内容阅读
目的动态监测急性脑梗死(ACI)患者血清S-100b蛋白的变化,探讨其与脑梗死体积、神经功能缺损程度及预后的关系。方法采用ELISA对50例颈内动脉系统ACI患者血清S-100b蛋白进行动态检测,并与30例对照组进行比较,同时进行神经功能缺损评分(NIHSS)及CT扫描测定脑梗死体积,随访2个月进行日常生活能力评分(BI)。结果ACI患者血清100b蛋白在入院第1d开始升高,第3d达到峰值,第7d下降,第14、21d与对照组无明显差异;第3d血清S-100b蛋白浓度高峰水平与脑梗死体积、神经功能缺损程度呈正相关,与2个月后BI呈负相关。结论急性脑梗死后血清S-100b蛋白可作为缺血性脑损伤的生化指标,并可评估预后,对脑梗死的临床治疗有指导意义。
Objective To dynamically monitor the change of serum S-100b protein in patients with acute cerebral infarction (ACI), and to explore its relationship with the volume of cerebral infarction, the degree of neurological deficit and prognosis. Methods Serum levels of S-100b protein in 50 patients with ACI in the internal carotid artery system were detected by ELISA and compared with 30 control subjects. Neurological deficit score (NIHSS) and CT scan were used to determine the infarct volume. Two follow-up Month for daily living ability score (BI). Results The serum level of 100b protein in ACI patients began to increase on the first day after admission, reaching the peak on the third day and decreasing on the 7th day. There was no significant difference on the 14th and 21st day between the control group and the serum S-100b protein level. The degree of functional impairment was positively correlated with BI after 2 months was negatively correlated. Conclusion Serum S-100b protein can be used as a biochemical indicator of ischemic brain injury after acute cerebral infarction, and prognosis can be assessed. It has guiding significance for the clinical treatment of cerebral infarction.