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已经发现20多种因素影响儿童急性淋巴细胞白血病(ALL)的预后。本研究是为了观察外周血原始细胞消失所需时间(原始细胞清除时间)是否影响儿童ALL患者对治疗的反应及预后。本组ALL患儿158例,平均年龄4.8岁,平均随访时间69个月(22-140个月)。研究结果:①本组原始细胞清除时间平均为6天(0-38天),大多数患儿(113/158例)的原始细胞清除时间≤1周;②原始细胞清除时间≤10天者预后无明显差异;③原始细胞清除时间分别为≤10天(138例)者,11-13天(11例)者与>13天(9例)者的5年无病存活率分别为60%,36%与17%;④多种因素分析表明原始细胞清除时间>10
More than 20 factors have been found to affect the prognosis of children with acute lymphoblastic leukemia (ALL). The purpose of this study was to observe whether the time required for the disappearance of peripheral blood progenitor cells (primary cell clearance time) affected the response and prognosis of children with ALL. In this group of 158 children with ALL, the average age was 4.8 years and the average follow-up time was 69 months (22-140 months). The results of the study: 1 The initial cell clearance time of the group was 6 days (0-38 days) on average, and the primary cell clearance time of most patients (113/158 cases) was ≤ 1 week; 2 The prognosis of the original cell clearance time was ≤10 days. There was no significant difference; 3 the original cell clearance time was ≤10 days (138 cases), 11-13 days (11 cases) and >13 days (9 cases) were 5 years disease-free survival rate was 60%, 36% and 17%; analysis of 4 factors showed that the initial cell clearance time was >10