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长期以来,胆脂瘤被认为是一种破坏性骨侵蚀的过程,已有许多解释其邻近骨质受侵蚀的学说:如压迫坏死,慢性骨髓炎,破骨细胞的骨溶解,酶介质的骨再吸收(胶原酶、溶菌酶等)和局部pH的改变等。Chole等最近在蒙古沙土鼠身上发现骨侵蚀性胆脂瘤,其行为和组织学表现与人类的相似。研究表明骨侵蚀发生在接近胆脂瘤的骨质表面,主要受多核破骨细胞的作用,然而其他的细胞也能破坏骨质,仅在破骨细胞侵蚀粗糙的边缘下面可看到骨质边缘层的局限性破坏。本研究系将屏障物植入在胆脂瘤推进的前方和耳蜗之间来确定侵蚀的机制。该屏障允许传送压力而阻止骨和胆脂瘤之间的直接接触,目的为判定是否必须直接接触胆脂瘤才产生破骨性骨再吸收。用年龄3～12个月的50只蒙古沙土鼠随机选入植入组。将高压消毒的屏障物植入鼓膜和耳蜗之间。使用的屏障物有:0.005英寸厚的硅
Cholesteatoma has long been considered a destructive process of bone erosion. There have been many explanations for the erosion of adjacent bones: compression necrosis, chronic osteomyelitis, osteoclast osteolysis, bone formation of the enzyme mediator Reabsorption (collagenase, lysozyme, etc.) and changes in local pH and so on. Recently, Chole et al found bone-erosive cholesteatoma in Mongolian gerbils and showed similar behavior and histology to humans. Studies have shown that bone erosion occurs on the surface of the bone adjacent to cholesteatoma and is primarily affected by multinucleated osteoclasts, whereas other cells can also destroy the bone and the bone margins can be seen just below the rough edges of the osteoclasts The limitations of layer damage. In this study, barriers were implanted in the front of advancing cholesteatoma and cochlear to determine the mechanism of erosion. This barrier allows delivery of pressure to prevent direct contact between bone and cholesteatoma in order to determine if direct contact with cholesteatoma is necessary to produce osteoclastic bone resorption. Fifty Mongolian gerbils, aged 3 to 12 months, were randomly selected for implantation. Autoclavable barrier is implanted between the tympanic membrane and the cochlea. The barriers used are: 0.005 inch thick silicon