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目的探讨成都地区糖耐量正常(NGT)者血糖水平变化特征。方法纳入50例NGT(男、女各25例)受试者,采用动态血糖监测系统(CGMS)进行连续72h血糖监测,分析日内平均血糖水平(MBG)、平均血糖波动幅度(MAGE)、日内血糖波动最大幅度(LAGE)、餐后血糖峰值(PPG)、餐后血糖波动幅度(PPGE)、三餐PPGE的均值(MPPGE)、日间血糖平均绝对差(MODD)、血糖波动的时间百分比。结果受试者血糖水平呈波动性变化,夜间及3餐前是血糖较低时段,日内血糖高峰多于餐后1～2h显现,尤以中、晚餐后为甚,且老年人群午餐后血糖波动幅度最大;本组NGT者MBG(5.9±1.2)mmol/L,MAGE(1.7±0.7)mmol/L,LAGE(4.4±1.9)mmol/L,PPG(8.7±1.7)mmol/L,MPPGE(2.3±1.6)mmol/L,MODD(0.75±0.79)mmol/L;78%(39例)的受试者血糖波动>7.8mmol/L,10%(5例)的血糖波动<2.8mmol/L,血糖波动于4.1～8.8mmol/L所占的日内时间百分比为95%(77%～100%)。结论成都地区NGT受试者存在血糖波动,CGMS有助于观察血糖波动并及时发现高血糖和无症状的低血糖。
Objective To investigate the changes of blood glucose level in normal glucose tolerance (NGT) patients in Chengdu. Methods A total of 50 subjects with NGT (25 males and 25 females) were enrolled in this study. Continuous 72-hour glucose monitoring was performed by dynamic blood glucose monitoring system (CGMS). The average daily blood glucose level (MBG), mean blood glucose level (MAGE) LAGE, PPG, PPGE, MPPGE, mean absolute difference of blood glucose during the day (MODD), percentage of time of blood glucose fluctuation. Results The blood glucose level of the subjects showed a fluctuant change. During the night and before the third meal, the blood glucose level was lower. The intra-day peak of blood glucose was more than that of the first postprandial 1-2h, especially after the middle and late supper. (5.9 ± 1.2) mmol / L, MAGE (1.7 ± 0.7) mmol / L, LAGE (4.4 ± 1.9) mmol / L and PPG (8.7 ± 1.7) mmol / L and MPPGE (0.75 ± 0.79) mmol / L and MODD (0.75 ± 0.79) mmol / L respectively; 78% (39 subjects) had a blood glucose fluctuation> 7.8mmol / L and 10% Blood glucose fluctuations in the 4.1 ~ 8.8mmol / L accounted for 95% of the time (77% to 100%). Conclusion There is blood glucose fluctuation in NGT subjects in Chengdu. CGMS can help observe the fluctuation of blood glucose and detect hyperglycemia and asymptomatic hypoglycemia in time.