Controlling paths of high-order harmonic generation from H+2 is theoretically investigated by numerically solving the time-dependent Schr(o)dinger equation based on the Bo-Oppenheimer approximation in orthogonal two-color fields. Our simulations show that the change of harmonic emission paths is dependent on time-dependent distribution of electrons. Compared with one-dimensional linearly polarized long wavelength laser, multiple retus are suppressed and short paths are dominant in the process of harmonic emission by two-dimensional orthogonalω/2ωlaser fields. Furthermore, not only are multiple retus weaken, but also the harmonic emission varies from twice to once in an optical cycle by orthogonalω/1.5ωlaser fields. Combining the time-frequency distributions and the time-dependent electron wave packets probability density, the mechanism of controlling paths is further explained. As a result, a 68-as isolated attosecond pulse is obtained by superposing a proper range of the harmonics.