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目的探讨联合检测胸水中癌胚抗原(CEA)、糖蛋白CA125和CA19-9对良恶性胸腔积液的鉴别诊断价值。方法应用化学发光分析法同时检测40例恶性胸腔积液和46例良性胸腔积液的CEA、CA125和CA19-9水平。结果恶性胸腔积液组的CA125、CAl9-9和CEA的含量显著高于良性胸腔积液组。联合检测能提高诊断恶性胸腔积液的敏感度和准确度。结论胸腔积液糖类抗原125、糖类抗原l9-9和癌胚抗原的联合检测对鉴别良恶性胸腔积液有重要价值。
Objective To investigate the value of combined detection of CEA, glycoproteins CA125 and CA19-9 in differential diagnosis of benign and malignant pleural effusions. Methods Chemiluminescence immunoassay was used to detect the levels of CEA, CA125 and CA19-9 in 40 patients with malignant pleural effusion and 46 patients with benign pleural effusion. Results The levels of CA125, CAl9-9 and CEA in malignant pleural effusion group were significantly higher than those in benign pleural effusion group. Joint detection can improve the sensitivity and accuracy of the diagnosis of malignant pleural effusion. Conclusions The combined detection of pleural effusion carbohydrate antigen 125, carbohydrate antigen 19-9 and carcinoembryonic antigen has important value in differentiating benign and malignant pleural effusions.