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目的探讨呼出气一氧化氮(FeNO)在哮喘患者诊断和治疗中的应用价值.方法采用病例对照研究的方法,将113例哮喘患者分为哮喘控制组、部分控制组和未控制组,30例健康人为对照组.采用呼出一氧化氮测定仪测定研究对象的 FeNO 浓度.结果哮喘组患者的 FEV1%、FEV1/FVC%均低于对照组,且单因素方差分析结果显示差异均有统计学意义(F=21.086,P<0.01;F=64.472,P<0.01);哮喘组患者的 FeNO 值均明显高于正常人,且单因素方差分析结果显示差异均有统计学意义(F=43.562,P0.05).结论呼出气一氧化氮测定在辅助评价哮喘患者诊断和治疗方面具有重要应用价值.“,” Objective To explore the diagnosis and treatment value of fraction of exhaled nitric oxide (FeNO) in patients with asthma. Methods A case control study was used, a total of 116 asthmatic patients were divided into controled asthma, partialy controled asthma, and uncontroled asthma groups. 30 healthy adults were enroled as controls. FeNO was measured for both asthmatic patients and healthy adults using the NIOXMINO. Results The asthma groups showed significantly lower FEV1% and FEV1/FVC% than the control group (F=21.086, P<0.01; F=64.472, P<0.01). The asthma groups showed significantly higher FeNO than the control group (F=43.562, P0.05). Conclusions The FeNO has important application value in the diagnosis and treatment of patients with asthma.