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目的：观察羊水栓塞样血浆（ＡＦＥＰ）与布洛芬血浆对兔离体灌流肺的影响。方法：羊水与血培养后离心制得ＡＦＥＰ，羊水、血和布洛芬一起培养后离心制得布洛芬血浆，在保持呼吸循环功能完整的兔离体肺灌流模型上，分别从肺动脉注入１０ｍｌＡＦＥＰ、布洛芬血浆、原羊水、羊水基液、兔血浆，用计算机系统记录肺动脉压、呼吸压和肺水肿发生情况，并与生理盐水灌流的兔离体肺（对照组）比较。结果：ＡＦＥＰ能导致肺动脉压明显升高（３．５２±０．６４ｋＰａ）（１ｋＰａ＝７．５ｍｍＨｇ）和肺水肿形成，布洛芬（１０ｍｇ／Ｌ）能降低ＡＦＥＰ所致的肺动脉高压（１．８７±０．４３ｋＰａ）和减轻肺水肿，原羊水、羊水基液和兔血浆均不能引起肺动脉压升高和肺水肿形成。结论：羊水进入血液循环可使血细胞释放血管活性物质并引起肺病变，布洛芬能部分缓解ＡＦＥＰＬ对肺的损害。
Objective: To observe the effect of amniotic fluid embolism-like plasma (AFEP) and ibuprofen plasma on perfused lung in vitro. Methods: After amniotic fluid and blood culture were centrifuged, AFEP, amniotic fluid, blood and ibuprofen were cultured together and centrifuged to produce ibuprofen plasma. In intact isolated rabbit lung perfusion model, The ibuprofen plasma, amniotic fluid, amniotic fluid and rabbit plasma were used to record the occurrence of pulmonary arterial pressure, respiratory pressure and pulmonary edema with computer system and compared with the isolated lung (control group). RESULTS: AFEP significantly increased pulmonary arterial pressure (3.52 ± 0.64 kPa) (1 kPa = 7.5 mm Hg) and pulmonary edema. Ibuprofen (10 mg / L) decreased pulmonary hypertension induced by AFEP (1. 87 ± 0.43kPa) and reduce pulmonary edema, the original amniotic fluid, amniotic fluid and rabbit plasma can not cause pulmonary hypertension and pulmonary edema formation. CONCLUSION: Amniotic fluid entering the blood circulation can release blood vasoactive substances from blood cells and cause pulmonary lesions. Ibuprofen can partially alleviate the lung damage caused by AFEPL.