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目的检测老年人群血尿酸(UA)水平,分析高尿酸血症(HUA)的相关危险因素。方法抽取6180例青年、5632例中年和5338例老年人静脉血,检测UA、空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平。分析HUA的相关危险因素。结果老年人UA水平和HUA患病率均高于中、青年人(P<0.01),且随体重指数(BMI)增加而升高;老年男性的UA水平和HUA患病率均高于老年女性(P<0.05或P<0.01)。Pearson相关分析显示,老年人UA水平与年龄、BMI和TG呈正相关(P<0.05),与FBG和HDL-C呈负相关(P<0.05)。Logistic回归分析显示,年龄、高TG和超重或肥胖是HUA的主要危险因素(P<0.05),而高FBG和高HDL-C为保护因素(P<0.05)。结论 HUA是老年人的高发病;其危险因素为年龄、高TG和超重或肥胖,保护因素为高FBG和高HDL-C。
Objective To detect the level of serum uric acid (UA) in the elderly and analyze the related risk factors of hyperuricemia (HUA). Methods The venous blood of 6180 young people, 5632 middle-aged and 5338 elderly people were collected for detection of UA, fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL- And high-density lipoprotein cholesterol (HDL-C) levels. Analysis of HUA related risk factors. Results The prevalence of UA and prevalence of HUA in the elderly were higher than those in the middle and young adults (P <0.01), and increased with the increase of the body mass index (BMI). The prevalence of UA and prevalence of HUA in the elderly were higher than those in the elderly (P <0.05 or P <0.01). Pearson correlation analysis showed that the level of UA in the elderly was positively correlated with age, BMI and TG (P <0.05), negatively correlated with FBG and HDL-C (P <0.05). Logistic regression analysis showed that age, high TG and overweight or obesity were the major risk factors for HUA (P <0.05), while high FBG and high HDL-C were protective factors (P <0.05). Conclusions HUA is a high incidence of the elderly. The risk factors are age, high TG, overweight or obesity, protective factors are high FBG and high HDL-C.