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目的:研究核因子E2相关因子2(Nrf2)在哈萨克族食管癌中的表达及意义。方法:应用免疫组化SP法检测Nrf2在80例哈萨克族食管癌患者,观察Nrf2的表达与食管鳞状细胞癌发生及浸润转移的关系。结果:Nrf2在哈萨克族食管癌组织中的阳性表达率为83.8%,高于癌旁组织的13.3%;低分化程度的Nrf2的阳性表达率分别为100%,高于中分化的82.6%,也高于高分化的72.7%;有淋巴结转移Nrf2的阳性表达率为97.7%高于无淋巴结转移的67.6%,差异均具有统计学意义。结论:Nrf2的高表达与哈萨克族食管癌的发生发展、淋巴结转移密切相关。
Objective: To study the expression of nuclear factor-2 (Nrf2) and its significance in Kazakh esophageal cancer. Methods: Immunohistochemical SP method was used to detect Nrf2 in 80 Kazakh esophageal cancer patients and to observe the relationship between Nrf2 expression and esophageal squamous cell carcinoma invasion and metastasis. Results: The positive expression rate of Nrf2 in Kazakh esophageal cancer tissues was 83.8%, which was higher than that in adjacent tissues (13.3%). The positive expression rates of poorly differentiated Nrf2 were 100%, higher than 82.6% of moderately differentiated Which was higher than that of well-differentiated 72.7%. The positive expression rate of Nrf2 with lymph node metastasis was 97.7%, which was higher than 67.6% without lymph node metastasis, the differences were statistically significant. Conclusion: The high expression of Nrf2 is closely related to the occurrence and development of Kazakh esophageal cancer and lymph node metastasis.