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目的探讨抗生素相关性肠炎(AAC)的有效治疗方案。方法将148例AAC患者随机分为A、B、C三组。三组患者均在采取综合措施基础上分别加用以下药物。A组(50例):口服枯草杆菌、肠球菌二联活菌肠溶胶囊,复方谷氨酰胺胶囊;B组(45例):口服甲硝唑片;C组(53例):口服枯草杆菌、肠球菌二联活菌肠溶胶囊、复方谷氨酰胺胶囊和甲硝唑片。分别观察腹泻的疗效与腹痛、腹胀和纳差等伴随症状缓解情况。结果治疗后腹泻缓解的总有效率分别为:A组76.0%,B组71.1%,两组差异无统计学意义(P>0.05);C组94.3%,与B组和A组比较,差异有统计学意义(P<0.01),且复发率低,差异有统计学意义(P<0.01);同时在缓解AAC伴随症状方面亦较单服甲硝唑片的疗效好,差异有统计学意义(P<0.01)。结论口服枯草杆菌、肠球菌二联活菌肠溶胶囊、复方谷氨酰胺胶囊和甲硝唑片是治疗AAC的有效方法,较单一类药物应用疗效佳。
Objective To investigate the effective treatment of antibiotic-associated enteritis (AAC). Methods 148 patients with AAC were randomly divided into A, B, C three groups. Three groups of patients were taken on the basis of comprehensive measures were added the following drugs. Group A (50 cases): Bacillus subtilis, enterococci enterococci enterotoxin capsules, compound glutamine capsules; Group B (45 cases): oral metronidazole tablets; Group C (53 cases): oral Bacillus subtilis , Enterococci two live bacteria enteric-coated capsules, compound glutamine capsules and metronidazole tablets. Respectively observed the efficacy of diarrhea and abdominal pain, abdominal distension and anorexia and other symptoms associated with remission. Results The total effective rate of diarrhea relief after treatment was 76.0% in group A and 71.1% in group B, respectively, with no significant difference between the two groups (P> 0.05). The difference between group B and group A was 94.3% (P <0.01), and the recurrence rate was low, the difference was statistically significant (P <0.01); at the same time in relieving the symptoms of AAC than curative effect of single metronidazole tablets, the difference was statistically significant P <0.01). Conclusion oral Bacillus subtilis, enterococci enterococci enteric-coated live capsule, compound glutamine capsules and metronidazole tablets is an effective method of treatment of AAC than a single class of drugs with good curative effect.