论文部分内容阅读
用原位杂交方法研究了人早期胎盘中组织型（ｔ）和尿激酶型（ｕ）纤溶酶原激活因子（ＰＡ）与其相应的抑制因子１型（ＰＡＩ－１）和２型（ＰＡＩ－２）ｍＲＮＡ的分布。结果表明：（１）在绒毛和蜕膜的血管壁，Ｒｏｈｒｓ和Ｎｉｔｓｂｕｃｈｈ纹间的蜕膜中的大部分外细胞滋养层细胞沿绒毛盘、基底盘、绒毛叶间隔和绒毛膜的细胞滋养层细胞以及蜕膜的腺体细胞中都检测到 ｔＰＡ， ｕＰＡ， ＰＡＩ－１和ＰＡＩ－２ ｍＲＮＡ；（２）在基底绒毛盘和隔组织或绒毛核间充质中都没有这些分子的表达．纤溶酶原激活因子和抑制因子在胎盘组织不同细胞中的协同表达可能在胎盘早期阶段从螺旋动脉转化为子官胎盘动脉中的血管发生和绒毛－蜕膜血流系统的建立以及胎盘的形成过程中起重要作用．
In situ hybridization was used to study the relationship between tissue type (t) and urokinase (PA) plasminogen activator (PA) and their PAI-1 and PAI- 2) mRNA distribution. The results showed that: (1) Most of the outer trophoblast cells in the vasculature of the villi and decidua, the decidua between the Rohrs and Nitsbuchh lines, along the villous disk, basal disk, villous septum and chorionic trophoblast And decidual glandular cells were detected tPA, uPA, PAI-1 and PAI-2 mRNA; (2) in the basal villus and septal or villous mesenchyme expression of these molecules are not. Synergistic expression of plasminogen activator and inhibitory factor in different placental cells may lead to the development of vascularization and villi-decidual flow in the placental arteries from the helical artery in the early placenta and the formation of the placenta Play an important role in the process.