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目的:了解武汉地区妇女人乳头瘤病毒(HPV)感染基因分型状况,为宫颈癌早期防治提供理论依据。方法:采用基因芯片技术对武汉地区1444例疑似HPV感染的妇女进行HPV检测,并作基因型别分析。结果:1444例妇女中共检出HPV阳性者580例,阳性率40.17%。检出高危基因型(HPV16、18、31、33、35、39、45、51、52、53、56、58、59、66、68、73、83和MM4型)511例,约占感染者的88%;检出低危型(HPV6、11、42和43型)69例,约占感染者的12%。在检出类型中单一感染495例,混合型感染85例。结论:HPV高危型与宫颈糜烂发病关系密切,积极控制HPV感染及有效治疗宫颈糜烂在宫颈癌早期防治中具有重要意义;基因芯片技术对HPV分型检测是一种快速、敏感和特异的方法。
Objective: To understand the genotyping status of human papillomavirus (HPV) infection in Wuhan women and to provide a theoretical basis for the early prevention and treatment of cervical cancer. Methods: The gene chip technique was used to detect HPV in 1444 women with suspected HPV infection in Wuhan and genotype analysis. Results: Among 1444 women, 580 were positive for HPV, the positive rate was 40.17%. 511 cases of high-risk genotypes (HPV16,18,31,33,35,39,45,51,52,53,56,58,59,66,68,73,83 and MM4 type) Of the 88 cases. The detection of low-risk type (HPV6, 11, 42 and 43) 69 cases, accounting for about 12% of infected persons. Among the detected types, 495 were single infection and 85 were mixed infection. Conclusion: HPV high risk type is closely related to the incidence of cervical erosion. Active control of HPV infection and effective treatment of cervical erosion are of great importance in the early prevention and treatment of cervical cancer. Gene chip technology is a rapid, sensitive and specific method for HPV typing detection.