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采用放射免疫法检测２５例结核性和３１例癌性胸膜炎患者血清和胸水中粒细胞－巨噬细胞集落刺激因子（ＧＭ－ＣＳＦ）浓度。结果发现，结核组血清ＧＭ－ＣＳＦ［（１９．５６±１２．６４）ｎｇ／Ｌ］明显高于正常组［（９．５２±３．６１）ｎｇ／Ｌ，Ｐ＜０．０１］和癌性组［（９．３５±６．１３）ｎｇ／Ｌ，Ｐ＜０．０１］，而癌性组与正常组比较无显著性差异（Ｐ＞０．０５）；结核组胸水ＧＭ－ＣＳＦ浓度［（２４．３４±１４．８６）ｎｇ／Ｌ］明显高于癌性组［（６．３５±３．１３）ｎｇ／Ｌ，Ｐ＜０．０１］。若以血清ＧＭ－ＣＳＦ１４ｎｇ／Ｌ为界限值，则结核组的敏感性为４８００％，特异性为８３８７％；若以胸水ＧＭ－ＣＳＦ９．５ｎｇ／Ｌ为界限值，则结核组的敏感性为８０００％，特异性为９０３２％。提示血清、胸水ＧＭ－ＣＳＦ测定对鉴别这两组胸膜炎有较高的价值，可作为鉴别结核性和癌性胸膜炎的一项检测指标。
Radioimmunoassay was used to detect the serum and pleural granulocyte-macrophage colony-stimulating factor (GM-CSF) concentrations in 25 patients with tuberculosis and 31 patients with cancerous pleurisy. The results showed that serum GM-CSF [(19.56±12.64) ng/L] was significantly higher in the tuberculosis group than in the normal group [(9.52±3.61) ng/L, P<0.01] and cancer In the sexual group [(9.35±6.13) ng/L, P<0.01], there was no significant difference between the cancerous group and the normal group (P>0.05); GM-CSF concentration in the pleural effusion in the tuberculosis group [(24.34±14.86) ng/L] was significantly higher than cancerous group [(6.35±3.13) ng/L, P<0.01]. If the serum GM-CSF is 14ng/L, the sensitivity of the tuberculosis group is 4800% and the specificity is 8387%; if the pleural fluid GM-CSF is 9.5ng/L, the tuberculosis group The sensitivity is 8000% and the specificity is 9032%. It is suggested that serum and pleural effusion GM-CSF assays have high value for the identification of these two groups of pleurisy and can be used as a detection index to identify tuberculous and cancerous pleurisy.