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肾上腺髓质素 (ADM)是一种多功能调节肽 ,体内分布广泛。ADM实现其多种生物学功能的物质基础是其受体的多样性及其调控的复杂性。ADM受体主要有CGRP1受体和孤儿G 蛋白偶联受体RDC 1、L1及降钙素受体样受体。ADM受体表型不仅取决于受体本身结构 ,还取决于受体活性修饰蛋白的调控及信号通路中受体成分蛋白的调节。此外 ,血循环中的ADM结合蛋白也从ADM的生物利用度及其与受体的相互作用等方面影响其生物学效应
Adrenomedullin (ADM) is a multifunctional regulatory peptide, widely distributed in the body. The material basis for ADM’s diverse biological functions is its receptor diversity and its regulatory complexity. ADM receptors are mainly CGRP1 receptor and orphan G protein-coupled receptors RDC 1, L1 and calcitonin receptor-like receptors. ADM receptor phenotype depends not only on the structure of the receptor itself, but also on the regulation of receptor activity-modifying proteins and the regulation of receptor component proteins in signaling pathways. In addition, ADM-binding proteins in the bloodstream also affect their biological effects from bioavailability of ADM and their interaction with receptors