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目的探讨经皮冠状动脉介入治疗(PCI)前给予强化他汀治疗对心肌损伤的保护作用及对患者血脂的影响。方法 80例不稳定型心绞痛患者随机分为他汀治疗组40例和对照组40例,他汀治疗组在PCI前7d使用阿托伐他汀40mg/d的治疗,对照组在PCI前不使用他汀类药物;两组患者其他常规治疗相同。比较患者PCI术后心肌损伤标记物和血脂水平的影响。结果治疗组和对照组PCI术后血中CRP含量均明显增加,治疗组在术后3d和术后1周时表现出血中CRP含量快速下降,与对照组比较差异有统计学意义(P<0.05)。治疗组在治疗后血脂水平较治疗前明显降低。结论急性冠状动脉综合征介入术前应用他汀类药物强化治疗安全性良好,不仅具有调脂作用,还具有降低PCI术后炎症反应的可能,而减少术后血管事件发生。
Objective To investigate the protective effect of statin therapy on myocardial injury before percutaneous coronary intervention (PCI) and its effect on serum lipids in patients. Methods A total of 80 patients with unstable angina were randomly divided into statin group (n = 40) and control group (n = 40). Statin group was treated with atorvastatin 40 mg / d 7 days before PCI, and no statin ; Other two groups of other conventional treatment the same. The effects of myocardial injury markers and serum lipids on PCI were compared. Results The levels of CRP in the treated group and the control group were significantly increased after PCI. The CRP level in the treated group decreased rapidly at 3 days and 1 week after the operation, showing significant difference compared with the control group (P <0.05 ). After treatment, the treatment group had significantly lower blood lipid levels than before treatment. Conclusions The pretreatment of acute coronary syndrome with statin therapy is safe and not only has lipid-lowering effect, but also reduces the possibility of inflammatory reaction after PCI and reduces postoperative vascular events.