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作者用L-PAM辅助乳腺根治术治疗原发性乳腺癌103例,所有患者腋淋巴结活检均阳性。材料和方法:治疗组103例乳腺术后2～4周起,每6周连续5天给予苯丙氨酸氮芥0.15毫克/公斤/天,药物剂量按毒性反应程度略加增减,疗程2年或确定治疗无效为止。对照组108例,术后不给L-PAM治疗。结果:对照组108例22%治疗失败,即活检或临床、病理、X线或同位素扫描确定局部、区域性或远处转移。治疗组103
The authors treated 103 cases of primary breast cancer with L-PAM assisted radical mastectomy. All patients had positive axillary lymph node biopsy. Materials and Methods: 103 patients in the treatment group received phenylalanine mustard 0.15 mg/kg/day for 5 consecutive days after 6 to 4 weeks after operation. The dose of the drug was slightly increased or decreased according to the degree of toxicity. Course of treatment 2 Year or determine that treatment is ineffective. 108 patients in the control group did not receive L-PAM after surgery. RESULTS: Of the 108 patients in the control group, 22% failed in treatment, ie, biopsy or clinical, pathological, X-ray or isotope scans identified local, regional, or distant metastases. Treatment group 103