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目的探讨P504S、P63在前列腺增生症、前列腺高级别上皮内瘤变(HGPIN)和前列腺癌中表达的意义。方法应用免疫组化Envision二步法检测一般前列腺增生症90例、HGPIN15例、前列腺癌20例组织中P504S、P63的表达情况。结果P504S、P63在一般前列腺增生症和前列腺癌中表达的阴阳性之间差异均有非常显著性。P504S在一般前列腺增生和HGPIN的表达也有非常显著的差异,其在HGPIN和前列腺癌的表达却差异无显著性。P63在一般前列腺增生和HGPIN的表达差异无显著性,在HGPIN和前列腺癌的表达却差异有显著性。结论P504S是前列腺癌敏感而特异性的标志物,需与P63联合应用,对前列腺疾病诸如前列腺增生、HGPIN以及前列腺癌的诊断具有重要价值。
Objective To investigate the expression of P504S and P63 in benign prostatic hyperplasia (BPH), high grade intraepithelial neoplasia (HGPIN) and prostate cancer. Methods Immunohistochemical Envision two-step method was used to detect the expression of P504S and P63 in 90 cases of general prostatic hyperplasia, 15 cases of HGPIN and 20 cases of prostate cancer. Results P504S, P63 in both benign prostatic hyperplasia and prostate cancer expression of the positive and negative differences between the very significant. There was also a very significant difference in the expression of P504S between normal prostatic hyperplasia and HGPIN. There was no significant difference in the expression of P504S between HGPIN and prostate cancer. There was no significant difference in the expression of P63 between normal prostatic hyperplasia and HGPIN, but there was significant difference between HGPIN and prostate cancer. Conclusion P504S is a sensitive and specific marker for prostate cancer. It needs to be used in combination with P63 and is valuable for the diagnosis of prostate diseases such as benign prostatic hyperplasia, HGPIN and prostate cancer.