论文部分内容阅读
目的 :探讨幽门螺杆菌L型 (Hp L)感染与食管癌的关系以及C erbB 2、p53表达在食管癌发生机制中的作用。方法 :应用免疫组化和革兰氏染色技术检测 1 2 6例食管癌和 40例对照组的Hp L型、C erbB 2、和p53基因蛋白 ,对Hp L型阳性和阴性组织的C erbB 2、和p53表达行比较分析。结果 :癌组的革兰氏染色L型检出率 (67.5 % )与对照组 (2 7.5 % )有显著性差异 (P <0 .0 5) ;与免疫组化Hp L型抗原表达阳性率 (65 .1 % )无显著性差异 (P >0 .0 5) ,Hp L型检出阳性率为 61 .9% (78/ 1 2 6)。癌组的C erbB 2、p53表达阳性率显著高于对照组。癌组中Hp L型感染阳性组的C erbB 2、p53表达阳性率也高于其Hp L型阴性组 ,其差异均有显著性 (P <0 .0 5)。表明Hp L型感染与食管癌相关 ,与食管癌的C erbB 2、p53过表达也相关。结论 :Hp L型与食管癌的发生有关 ,有可能通过致基因突变而涉及食管癌的发生过程
Objective: To investigate the relationship between Helicobacter pylori (Lp) infection and esophageal cancer and the role of C erbB 2 and p53 in the pathogenesis of esophageal cancer. Methods: The Hp L, C erbB 2 and p53 gene proteins were detected by immunohistochemistry and Gram staining in 126 esophageal cancer patients and 40 control subjects. The expression of C erbB 2 in Hp L positive and negative tissues , And p53 expression line comparative analysis. Results: The detection rate of gram-positive L-type in cancer group (67.5%) was significantly different from that in control group (7.5%) (P <0.05). The positive rate of Hp L antigen expression (65.1%) had no significant difference (P> 0.05). The positive rate of Hp L type detection was 61.9% (78/126). The positive rate of C erbB 2 and p53 in cancer group was significantly higher than that in control group. The positive rate of C erbB 2 and p53 in Hp L-positive group was also higher than that in Hp L-negative group (P <0.05). Hp L infection is associated with esophageal cancer and is associated with overexpression of C erbB 2 and p53 in esophageal cancer. Conclusion: The Hp L type is associated with the occurrence of esophageal cancer and may involve esophageal carcinogenesis through gene mutation