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重症肌无力(MG)是在神经-肌肉接头处存在电生理及结构上缺陷的一种突触病变,但引起肌肉功能障碍的真正原因至今尚不清楚。自1960年Simpson首次提出该病的自身免疫假说以来,有关MG病因的研究甚多,产生了许多实验性假说,其中最为大家所注意的则是MG与胸腺的关系。目前有大量资料,如MG与其他自身免疫性疾病间的联系;胸腺异常者MG发病率高;胸腺切除、皮质类固醇、免疫抑制剂及血浆交换治疗,都
Myasthenia gravis (MG) is a synaptic lesion with electrophysiological and structural defects at the neuromuscular junction, but the exact cause of muscle dysfunction remains unclear. Since Simpson first proposed the autoimmune hypothesis of the disease in 1960, there have been many studies on the etiology of MG. Many experimental hypotheses have been made, of which the most notable one is the relationship between MG and thymus. There is a wealth of information currently available, such as the link between MG and other autoimmune diseases, high incidence of MG in patients with abnormal thymic disease, thymus resection, corticosteroids, immunosuppressive agents and plasma exchange therapy